Stefan Leutgeb

Peer-reviewed Publications



  • Sabariego M, Schonwald A, Boublil BL, Zimmerman DT, Ahmadi S, Gonzalez N, Leibold C, Clark RE, Leutgeb JK, Leutgeb S. Time Cells in the Hippocampus Are Neither Dependent on Medial Entorhinal Cortex Inputs nor Necessary for Spatial Working Memory. Neuron. doi: 10.1016/j.neuron.2019.04.005. [PDF]

  • Chenani A*, Sabariego M*, Schlesiger MI, Leutgeb JK, Leutgeb S, Leibold C. Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex. Nat Commun. doi: 10.1038/s41467-019-09280-0. *These authors contributed equally. [PDF]

  • Sousa AF, Cowansage KK , Zutshi I, Cardozo LM, Yoo EJ, Leutgeb S, Mayford M. Optogenetic reactivation of memory ensembles in the retrosplenial cortex induces systems consolidation. PNAS. doi:10.1073/pnas.1818432116. [PDF]

  • Diehl GW, Hon OJ, Leutgeb S, Leutgeb JK. Stability of medial entorhinal cortex representations over time. Hippocampus, 29:284-302. [PDF]

  • Ewell LA, Fischer KB, Leibold C, Leutgeb S, Leutgeb JK. The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy. eLife. doi: 10.7554/eLift.42148. [PDF]

    • Ewell LA, Fischer KB, Leibold C, Leutgeb S, Leutgeb JK. Data from: The impact of pathological high frequency oscillations on hippocampal network activity in rats with chronic epilepsy. Dryad Digital Repository. doi:10.5061/dryad.c89124p. [Resource Link]

  • Mankin EA, Thurley K, Chenani A, Haas O, Debs L, Henke J, Galinato M, Leutgeb JK, Leutgeb S, Leibold C. The hippocampal code for space in Mongolian gerbils. Hippocampus, doi:10.1002/hipo.23075. [PDF]


  • Zutshi I, Fu ML, Lilascharoen V, Leutgeb JK, Lim BK, Leutgeb S. Recurrent circuits within medial entorhinal cortex superficial layers support grid cell firing. Nat Commun, 9: 3701. doi: 10.1038/s41467-018-06104-5. [PDF]

  • Meng D, Li H, Leutgeb S, Deisseroth K, Spitzer NC. Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress. Proc Natl Acad Sci USA. 115:5064-5071. [PDF]

  • Zutshi I*, Brandon MP*, Fu ML, Donegan ML, Leutgeb JK, Leutgeb S. Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies. Curr Biol. 28:1179-1188. *These authors contributed equally. [PDF]

  • Schlesiger MI, Boublil BL, Hales JB, Leutgeb JK, Leutgeb S. Hippocampal global remapping can occur without input from the medial entorhinal cortex. Cell Rep. 22:3152-3159. [PDF]

  • Sasaki T*, Piatti VC*, Hwaun E, Ahmadi S, Lisman JE, Leutgeb S, Leutgeb JK. Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons. Nat Neurosci,21:258-269. *These authors contributed equally. [PDF]


  • Zutshi I, Leutgeb JK, Leutgeb S. Theta sequences of grid cell populations can provide a movement-direction signal. Curr Opin Behav Sci. 17:147-154. [PDF]

  • Diehl GW, Hon OJ, Leutgeb S, Leutgeb JK. Grid and non-grid cells in medial entorhinal cortex represent spatial location and environmental features with complementary coding schemes. Neuron 94, 83-92. [PDF]

    • Reviewed in Faculty of 1000 Prime. [Link]


  • Ewell LA, Liang L, Armstrong C, Soltész I, Leutgeb S, Leutgeb JK. Brain state is a major factor in preseizure hippocampal network activity and influences success of seizure intervention. J Neurosci 35, 15635-48. [PDF]

    • Reviewed and highlighted in Epilepsy Currents. [Link]

  • Schiller D, Eichenbaum H, Buffalo EA, Davachi L, Foster DJ, Leutgeb S, Ranganath C. Memory and Space: Towards an Understanding of the Cognitive Map. J Neurosci 35:13904-13911. [PDF]

  • Schlesiger MI*, Cannova CC*, Boublil BL, Hales JB, Mankin EA, Brandon MP, Leutgeb JK, Leibold C, Leutgeb S. The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity. Nat Neurosci 18, 1123-1132. *These authors contributed equally. [PDF]

  • Mankin EA, Diehl GW, Sparks FT, Leutgeb S, Leutgeb JK. Hippocampal CA2 activity patterns change over time to a larger extent than between spatial contexts. Neuron 85 190-201. [PDF]

    • Featured article with accompanied Preview article in Neuron. [Link]


  • Ewell LA, Leutgeb S. Replay to remember: a boost from dopamine. Nat Neurosci 17, 1629-31. News and Views. [PDF]

  • Sasaki T, Leutgeb S, Leutgeb, JK. Spatial and memory circuits in the medial entorhinal cortex. Curr Opin Neurobiol 32C, 16-23. [PDF]

  • Hales JB*, Schlesiger MI*, Leutgeb JK, Squire LR, Leutgeb S**, Clark RE**. Medial entorhinal cortex lesions only partially disrupt hippocampal place cells and hippocampus-dependent place memory. Cell Reports 9, 893-901. *These authors contributed equally. **These authors contributed equally. [PDF]

    • Reviewed in Faculty of 1000 Prime. [Link]

  • Brandon, MP, Koenig J, Leutgeb JK, and Leutgeb S. New and distinct hippocampal place codes are generated in a new environment during septal inactivation. Neuron 82, 789-96. [PDF]

    • Featured article with accompanied Preview article in Neuron. [Link]

    • Reviewed in Faculty of 1000 Prime. [Link]

  • Brandon MP, Koenig J, Leutgeb S. Parallel and convergent processing in grid cell, head-direction cell, boundary cell, and place cell networks. Wiley Interdiscip Rev Cogn Sci 5, 207-219. [PDF]


  • Lu L*, Leutgeb JK*, Tsao A, Henriksen EJ, Leutgeb S, Barnes CA, Witter MP, Moser MB, Moser EI. Impaired hippocampal rate coding after lesions of the lateral entorhinal cortex. Nature Neuroscience 16, 1085-1093. *These authors contributed equally. [PDF]

  • Dulcis D, Jamshidi P, Leutgeb S, Spitzer NC. Neurotransmitter switching in the adult brain regulates behavior. Science 340, 449-453. [PDF]

  • Schlesiger MI, Cressey JC, Boublil B, Julie Koenig J, Neal R. Melvin NR, Leutgeb JK, Leutgeb S. Hippocampal activation during the recall of remote spatial memories in radial maze tasks. Neurobiol Learn Mem 106, 324-333. [PDF]


  • Mankin EA, Sparks FT, Slayyeh B, Sutherland RJ, Leutgeb S, Leutgeb JK. A neuronal code for extended time in the hippocampus. Proc Natl Acad Sci U S A 109, 19462-19467. [PDF]

    • Reviewed in Faculty of 1000 Prime. [Link]


  • Koenig J, Linder AN, Leutgeb JK, Leutgeb S. The spatial periodicity of grid cells is not sustained during reduced theta oscillations. Science 332, 592-595. [PDF]

    • Publication was reviewed and highlighted in Nature Reviews Neuroscience. [Link]

    • Reviewed in Faculty of 1000 Prime. [Link]


  • Leutgeb JK, Leutgeb S. Book review: The dentate gyrus: a comprehensive guide to structure, function, and clinical implications. Hippocampus 20, 226-228. [PDF]

  • Colgin LL*, Leutgeb S*, Jezek K, Leutgeb JK, Moser EI, McNaughton BL, Moser MB. Attractor-map versus autoassociation based attractor dynamics in the hippocampal network. J Neurophysiol. 104, 35-50. *These authors contributed equally. [PDF]

  • Alme CB, Buzzetti RA, Marrone DF, Leutgeb JK, Chawla MK, Schaner MJ, Bohanick JD, Khoboko T, Leutgeb S, Moser EI, Moser MB, McNaughton BL, Barnes CA. Hippocampal granule cells opt for early retirement. Hippocampus 20, 1109-1123. [PDF]


  • Kjelstrup KB, Solstad T, Brun VH, Hafting T, Leutgeb S, Witter MP, Moser EI, Moser MB. Finite scale of spatial representation in the hippocampus. Science 321, 140-143. [PDF]

  • Leutgeb S. Detailed differences. Science 319, 1623-1624. Perspective. [PDF]

  • Brun VH, Leutgeb S, Wu H-Q, Schwarcz R, Witter MP, Moser EI and Moser M-B. Impaired spatial representation in CA1 after lesion of direct input from entorhinal cortex. Neuron 57, 290-302. [PDF]


  • Leutgeb S, Leutgeb JK. Pattern separation, pattern completion, and new neuronal codes in a continuous CA3 map. Learn Mem 14, 745-757. [PDF]

  • Leutgeb JK, Leutgeb S, Moser M-B, Moser EI. Distinct mechanisms for pattern separation in dentate gyrus and CA3 of the hippocampal formation. Science 315, 961-966. [PDF]


  • Leutgeb S, Leutgeb JK, Moser EI, Moser M-B. Fast rate coding in hippocampal CA3 cell ensembles. Hippocampus 16, 765-774. [PDF]


  • Leutgeb JK, Leutgeb S, Treves A, Meyer R, Barnes CA, McNaughton BL, Moser M-B, Moser EI. Progressive transformation of hippocampal neuronal representations in "morphed" environments. Neuron 48, 345-358. [PDF]

    • Featured article with accompanied Preview article in Neuron. [Link]

    • Reviewed in Faculty of 1000 Prime. [Link]

  • Leutgeb S, Leutgeb JK, Barnes CA, Moser EI, McNaughton BL, Moser M-B. Independent codes for spatial and episodic memory in hippocampal neuronal ensembles. Science 309, 619-623. [PDF]

    • Publication was accompanied by a Perspective in Neuroscience. [Link]

    • Reviewed in Faculty of 1000 Prime. [Link]

  • Oliva D, Samengo I, Leutgeb S, Mizumori S. A subjective distance between stimuli: quantifying the metric structure of representations. Neural Comput 17, 969-90. [PDF]


  • Leutgeb S, Leutgeb JK, Treves A, Moser M-B, Moser EI. Distinct Ensemble Codes in Hippocampal Areas CA3 and CA1. Science 305, 1295-1298. [PDF]

    • Publication was accompanied by a Perspective in Science. [Link]

    • Reviewed in Faculty of 1000 Prime. [Link]


  • Leutgeb S, Mizumori SJY. Context-specific spatial representations of lateral septal cells. Neuroscience 105, 655-663. [PDF]

  • Bezzi M, Samengo I, Leutgeb S, Mizumori SJY. Measuring information spatial densities. Neural Computation 14,405-420. [PDF]


  • Mizumori SJY, Leutgeb S. Directing place representations in hippocampus. Rev Neurosciences 12, 347-63. [PDF]

  • Ragozzino KE, Leutgeb S, Mizumori SJY. Simultaneous recordings of dorsal striatal head direction cells and hippocampal place cells during spatial performance by rats. Exp Brain Res 139, 372-376. [PDF]


  • Mizumori SJY, Cooper BG, Leutgeb S, Pratt WE. A neural systems analysis of adaptive navigation.  Molec Neurobiol 21, 57-82. [PDF]

  • Leutgeb S, Ragozzino KE, Mizumori SJY. Convergence of head direction and place information in the CA1 region of hippocampus. Neuroscience 100, 11-19. [PDF]


  • Mizumori SJY, Leutgeb S. Interpreting neural representations of aged animals. Hippocampus 9:607-608. Commentary. [PDF]

  • Leutgeb S, Mizumori SJY. Excitotoxic septal lesions result in spatial memory deficits and altered flexibility of hippocampal single-unit representations. J Neurosci 19, 6661-6672. [PDF]

  • Mizumori SJY, Ragozzino KE, Cooper BG, Leutgeb S. Hippocampal representational organization and spatial context. Hippocampus 9, 444-451. [PDF]


  • Schmolesky MT, Wang Y, Hanes DP, Thompson KG, Leutgeb S, Schall JD, Leventhal AG. Signal timing across the macaque visual system. J Neurophysiol 79, 3272-3278. [PDF]


  • Leutgeb S, Husband S, Riters LV, Shimizu T, Bingman VP. Telencephalic afferents to the caudolateral neostriatum of the pigeon. Brain Res 730, 173-181. [PDF]


Book Chapters



  • Leutgeb JK, Leutgeb S. The contribution of hippocampal subregions to memory coding. In: The Cognitive Neurosciences, 5th Edition (Gazzaniga, M, Ed.) MIT Press. Book chapter.

  • Leutgeb S, Leutgeb JK. Remapping to discriminate contexts with hippocampal population codes. In: Space, Time, and Memory in the Hippocampal Formation (Derdikman D; Knierim JJ, Eds.). Springer, Dordrecht. Book chapter.


  • Leutgeb JK, Mankin EA, Leutgeb S. Population coding by place cells and grid cells. In: Principles of neural coding (Panzeri S and Quian R, Eds.). CRC Press. Book chapter.