BIOLOGICAL SCIENCES at university of California, sAN dIEGO
Learning & Memory Group
Our laboratories study these questions with an emphasis on one of the core systems for memory, which includes the hippocampus and entorhinal cortex. In humans, these brain regions are known to be the basis for declarative memory – the form of memory that we are aware of and can recollect when being asked. In addition, the hippocampus and associated brain regions are also critically important for perceiving space and for navigating in familiar and new environments.
While tremendous progress has been made in identifying cellular, molecular, and neural circuits for learning, memory, and navigation, our understanding of the computations that the brain performs to support these functions are incompletely understood. Our laboratories focus on identifying these biological computations and we are also interested in how multiple brain regions cooperatively engage in memory-related function.
news & events
What’s New?
10/30/2023 Congratulations Silvia and colleagues for your recent publication in Neuron.
04/01/2023 Congratulations Mengni on receiving the KIBM Postdoctoral Scholars Award!
05/31/2022 Congratulations Brandon for successfully defending your Master's thesis!
10/04/2021 Congratulations Clare, Ipshita and colleagues for your recent publication in Nature Neuroscience.
06/22/2021 Congratulations Sunandha for successfully defending your PhD thesis!
06/10/2021 Congratulations Adeh, Ameen, and Yudi for successfully defending your Master's theses.
12/07/2020 Congratulations Sia for successfully defending your PhD thesis!
07/01/2020 Congratulations Dylan and Rina for your graduate school acceptances!
06/07/2020 Best of luck Silvia for starting your own lab at DZNE Berlin.
Congratulations Thao for your acceptance into Pharmacy School!
06/06/2020 Congratulations Rina and Naomie on successfully defending your Master’s theses.
04/29/2020 See Li and Stefan’s recent news & views in Nature Neuroscience.
01/31/2020 Naomie and Rina presented posters at Lab Expo UCSD.
10/20/2019 Sia and Lorenzo presented posters at the SfN Conference in Chicago.
08/30/2019 Congratulations Clare on successfully defending your PhD thesis.
06/14/2019 Congratulations Antonia and Kshitij for your acceptance into medical school.
Congratulations Chris for your acceptance into graduate school.
05/30/2019 Congratulations Kshitij on successfully defending your Master’s thesis.
05/09/2019 Best of luck to Marta on starting her own lab at Mount Holyoke.
05/02/2019 Congratulations Marta and colleagues on publishing a paper in Neuron.
03/22/2019 Congratulations Alireza, Marta and colleagues on publishing a paper in Nature Communication.
02/22/2019 Congratulations Laura and colleagues on publishing a paper in eLife.
02/15/2019 Congratulations Emily and colleagues on publishing a paper in Hippocampus.
01/11/2019 Congratulations Ipshita on completing your PhD! We made a video to show you how much we'll miss you.
We know you will make an exceptional postdoc in the Buzsaki lab. Don't forget to Invite Us to New York!
11/14/2018 We welcomed Lucas as the youngest member of our lab! Congratulations Sílvia on your beautiful baby.
11/06/2018 We presented eight posters at the SfN Conference in San Diego. Check out our pictures.
10/11/2018 Congratulations Ipshita on receiving the Biology Founding Faculty Awards for Graduate Excellence.
09/15/2018 Congratulations Silvia on receiving the Innovation Research Grant from the Kavli Insitute for Brain and Mind.
09/12/2018 Congratulations Ipshita and colleagues on publishing a paper in Nature Communication.
09/02/2018 Congratulations Geoffrey and colleagues on publishing a paper in Hippocampus.
07/13/2018 We would like to wish the best of luck to Geoffrey and Anna-Lena in their new labs.
06/20/2018 We attended the iNav Conference in Mont Tremblant, Canada. Check out our pictures!
06/15/2018 Congratulations Kshitij on receiving the Excellence in Teaching Award.
05/03/2018 Congratulations Ario for your acceptance into medical school.
05/12/2018 Congratulations Geoffrey on successfully defending your PhD thesis.
04/23/2018 Congratulations Ipshita, Mark and colleagues on publishing a paper in Current Biology.
03/20/2018 Congratulations Magdalene and colleagues for your published paper in Cell Report.
01/15/2018 Congratulations to Takuya, Vero and colleagues for publishing a paper in Nature Neuroscience.
11/12/2017 Sílvia, Geoff and Marta presented their posters at the SfN Conference in Washinton, DC.
09/30/2017 Congratulations Gabrielle on receiving the UCSD Equity, Diversity, and Inclusion Fellowship.
05/25/2017 Congratulations Geoffrey on receiving the Leon Thal Award for outstanding scholarship among Neurosciences Graduate students.
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Silva et al. 2023
Neuron
Expression of human mutant APP in a select hippocampal neuronal population confirmed that progressive cognitive decline in Alzheimer's disease (AD) can be caused by an initially focal pathology that causes aberrant neuronal activity in a larger network rather than by a spreading molecular pathway. Learn more.
Quirk et al. 2021
Nature Neuroscience
By experimentally taking over the local theta frequency in the hippocampus and entorhinal cortex we found the very small increases in frequency were sufficient to disrupt working memory by interfering with neural computations during the encoding phase of a spatial working memory task. This work confirms the causal role of theta oscillations for memory encoding. Learn more.
Sabariego et al. 2019
Neuron
Memory maintenance over short intervals is thought to depend on sustained neural activity in the hippocampus that represents memory content. However, Sabariego et al. find that hippocampal time cells are not necessary for memory retention over short time periods. Learn more.
Ewell et al. 2019
eLife
In epilepsy, brain networks generate pathological high-frequency oscillations (pHFOs) during interictal periods. Ewell et al. present a novel framework for separating normal and pHFOs in the epileptic brain and uncover new mechanisms for impaired hippocampal network function in epilepsy. Learn more.
