BIOLOGICAL SCIENCES at university of California, sAN dIEGO
Learning & Memory Group
Our laboratories study these questions with an emphasis on one of the core systems for memory, which includes the hippocampus and entorhinal cortex. In humans, these brain regions are known to be the basis for declarative memory – the form of memory that we are aware of and can recollect when being asked. In addition, the hippocampus and associated brain regions are also critically important for perceiving space and for navigating in familiar and new environments.
While tremendous progress has been made in identifying cellular, molecular, and neural circuits for learning, memory, and navigation, our understanding of the computations that the brain performs to support these functions are incompletely understood. Our laboratories focus on identifying these biological computations and we are also interested in how multiple brain regions cooperatively engage in memory-related function.
news & events
Memory maintenance over short intervals is thought to depend on sustained neural activity in the hippocampus that represents memory content. However, Sabariego et al. find that hippocampal time cells are not necessary for memory retention over short time periods. Learn more.
Congratulations Dr. Ipshita Zutshi! Your thesis defense has only further confirmed your hippocampus is highly functional. Here are some pictures.
The medial entorhinal cortex (mEC) is a brain region thought to be critical for navigation. Zutshi et al. help to refine several long-standing theories that model how grid cell firing might arise and provide experimental evidence that local connections within mEC play a role in grid cell firing. Learn more.
Last November, we presented our latest research projects with eight different posters at the Society for Neuroscience conference in San Diego. Check out our pictures.
Complex spatial working memory tasks have been shown to require both hippocampal sharp-wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. Sasaki et al. ask whether DG inputs to CA3 contribute to spatial working memory by promoting SWR generation. Learn more.
Thank you iNAV for making us step outside of our comfort zone both as scientists and zip-line enthusiasts. We also want to congratulate Ipshita on winning the Data Blitz competition for Best Speaker. Here are some pictures.